A1

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A1 is an interneuron in Pleurobranchaea

NeuronBank Accession ID: Ple0002601

Homologous to C2 in Tritonia

Anatomy

  • Soma:
    • Coloration: White
    • Location: The larger, more anterolateral of the two white cells in the A cluster of the of the cerebral ganglion.
    • size: 50 -110 microns in animals 10 - 600 gm - slightly larger than nearby neurons
  • Axon Projection: Contralateral through cerebral commissure, then through anterior cerebropedal connective to pedal ganglion, then through pedal commissure

Electrophysiology

  • Resting Membrane Potential: -48.6 mV
  • Spike Height: 70.3 mV

Synapses

Inputs

  • Excited by sensory afferents - no indication of whether this is mono or polysynaptic
  • Electrically coupled to A3 and inhibited by A3

Outputs

  • Polysynaptic inhibition of Phasic Paracerebral Neuron (PCp)

Behavior

  • A1 is a member of the swim CPG circuit. It is rhythmically active during the swim motor pattern and can reset the motor pattern.
  • A1 stimulation inhibits feeding.
  • Stimulation of A1 in non-swimming whole-animal preparation has a biphasic effect:
  1. The animal straightens like a dorsal flexion
  2. The animal turns to the side contralateral to the A1 soma being stimulated.


References

  • J. Jing and R. Gillette. Neuronal elements that mediate escape swimming and suppress feeding behavior in the predatory sea slug Pleurobranchaea. J.Neurophysiol. 74 (5):1900-1910, 1995.PMID:8592183
  • J. Jing and R. Gillette. Central pattern generator for escape swimming in the notaspid sea slug Pleurobranchaea californica. J.Neurophysiol. 81 (2):654-667, 1999. PMID:10036268