Basket Cells (Basket neurons) are neurons found in the cerebellum whose terminal axons form a basket-like nest in which Purkinje cells rest.
Basket Cells are neurons located in the cerebellum of vertebrates. Cerebellar basket cells make inhibitory synaptic contacts with neighboring cell (Purkinje cells) and control the overall potentials on target cells. Basket cells have distint axonal aborization morphology that enable them to effectively control the gain of synaptic potentials and action potential discharge of target cells.
Neuronal Type: local interneuron
"Basket cells are multipolar, stellate, and contain free branching dendrites whose diameters vary from 12 to 30mm and whose bodies are located in molecular layers. The dendrites are smooth, but some have spines. These cerebellar basket cells are different from other interneurons by their axons. Their axons pass in the vertical and horizontal directions forming tree-like structure, and axon terminals have beads and basket-like network."
- Neurotransmitter: GABA (Gamma-Aminobutyric acid), the inhibitory neurotransmitter in the vertebrate nervous system. Also, presynaptic terminals of cerebellar basket cells are known to contain ryanodine-sensitive calcium stores (RyCSs). Calcium released from presynaptic RyCSs enhances the amplitude of evoked GABAergic synaptic currents.
Axon collaterals of basket cells make contact with Purkinje cells (the sole efferent output of the cerebellar cortex). Being an inhibitory neuron, basket cells fire inhibitory neurotransmitters, such as GABA into their synaptic terminal and inhibit Purkinje cells. Basket cell terminals are also rich in voltage-gated potassium channels. These voltage-gated potassium channels associate with calcium present in the intracellular space of synaptic terminals thereby increasing the action potential rate at which the neurons are transmitting.
Purkinje cell bodies that make synaptic connections with basket cells receive inhibitory neurotransmitter, GABA, and Potassium from basket cells. Received inhibitory projections are sent to the deep cerebellar nuclei, and constitute the output of motor coordination in the cerebellar cortex.
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